DNA Gut tests and reports on evidence-based, clinically useful, human genetic variants that predispose individuals to alterations in gut homeostasis. These alterations are known to have negative consequences for human health.
The report offers personalised diet, lifestyle and nutraceutical interventions to support relevant pathways and help you achieve and maintain a healthy and resilient gastrointestinal tract.
Clinical Value:
There is significant evidence highlighting the link between how the Gut Microbiota impacts our genes.
Gut bacteria produce a vast array of compounds (microbial metabolites) which act as messengers, these metabolites can directly or indirectly influence our gene expression. Microbes also influence the expression of genes involved in immune responses and the expression of genes related to lipid metabolism, glucose regulation, and nutrient absorption.
On the other hand, the human genome plays a major role in our gut health by
- Shaping our gut environment through immune system genes that regulate which bacteria can colonize the gut, encoding proteins that create our gut lining and its protective mucus layer, and encoding digestive enzymes responsible for breaking down food.
- Influencing nutrient availability by determining how our bodies process and absorb nutrients and what substrates and cofactors are available to important gut enzymes and gut microbiota.
Genetic variants that play a role in these areas may weaken one of the five DNA Gut pillars, which increases risk for altered gut homeostasis, dysbiosis and predisposition for gut-related health disorders.
The test should be considered for those who are suffering from, or have a predisposition to:
- Irritable bowel syndrome (IBS)
- Chronic bloating, diarrhoea, or constipation
- Inflammatory bowel disease (IBD) including ulcerative colitis and Crohn’s disease
- Coeliac disease or non-coeliac gluten sensitivity
- gut dysbiosis, non-coeliac gluten sensitivity or
- Lactose intolerance
- Food sensitivities
- Autoimmune tendencies and recurrent infections
- Mental health conditions linked to gut health including mood, cognition, and neurodegenerative conditions
- Anyone seeking preventative, root-cause care
The report provides:
- A summary of prioritised pathways
- Genetic variants that impact the Five DNA Gut Health Pillars – Motility, Presence of pathobionts, Aberrant microbial metabolite production, Gut barrier integrity, Immune function
- Gut health predispositions presented as colour-coded areas of potential risk
- Gene, and genotype-specific information that is evidence based and clinically relevant
- Impact of the gene variant on disease risk and how it affects gut health
- The Clear explanations and visuals for each gene variant and pathway, coupled by targeted recommendations for diet, supplements, probiotics, and lifestyle and prompts for further testing (GI-MAP, Zonulin, Gluten Peptide, Stool OMX, SIBO, Toxin Panels etc.)
Assessment of:
26 genetic variants involved in:
- Gut-brain axis
- Blood group antigen secretor
- Bacterial sensing and autophagy
- Tight junction proteins
- Vitamin D
- Inflammation
- Oxidative stress
- Detoxification
- Serotonergic pathway
- Gluten Intolerance
- Starch degradation
- Lactose intolerance
Knowledge of genetic risk variants together with functional testing enables better understanding of the patient’s symptom set and allows for deep insights into the driving factors leading to disease development.